THE EFFECT OF CMV INFECTION ON PROGRESSION OF HUMAN-IMMUNODEFICIENCY-VIRUS DISEASE IN A COHORT OF HEMOPHILIC MEN FOLLOWED FOR UP TO 13 YEARS FROM SEROCONVERSION

The effect of prior infection with cytomegalovirus (CMV) on progression of HIV disease in a cohort of 111 men with haemophilia was studied after 13 years followup. The relative hazards associated with CMV positivity on progression to AIDS, death and a CD4 count of 0.05 x 10(9)/l were 2.28, 2.42 and 2.34, respectively. CMV seropositive patients were significantly older than the seronegative and this was controlled for by using a Cox proportional hazards model. The relative hazards for the three endpoints decreased to 1.89, 1.82 and 1.93 respectively and were marginally non-significant (P = 0.05, 0.08 and 0.08 for the three endpoints respectively). We conclude that this cohort continues to show evidence of a 'co-factor' effect associated with prior infection with CMV which is confounded by age but not completely explained by age differences. The potential biological significance of these results is discussed in the context of recent controlled clinical trials which show a survival benefit from long-term high-dose acyclovir, a drug with activity in vivo against CMV and other herpesviruses

The rate of CD4 decline as a determinant of progression to AIDS independent of the most recent CD4 count

The data of two cohort studies of HIV-infected individuals were used to examine whether the rate of CD4 decline is a determinant of HIV progression, independent of the most recent CD4 count. Time from seroconversion to clinical AIDS was the main outcome measure. Rates of CD4 decline were estimated using the ordinary least squares regression method. AIDS incidences were compared in individuals who had previously experienced either a steeper or a less steep rate of CD4 decline. Cox proportional hazards model including a time-dependent covariate for the rate of CD4 decline was performed. The rate of prior CD4 decline was significantly associated with the risk of developing AIDS independently from the most recent CD4 count, with a 2 % increase in hazard of AIDS (P < 0.01) for a difference of 10 cells/mm(3) in the estimated yearly drop in CD4 count. This finding gives scientific credit to the belief that individuals with a prior steeper CD4 decline consistently have a higher subsequent risk of developing AIDS than those with a less steep prior decline

Experimental Analysis of Algorithms for Coflow Scheduling

Modern data centers face new scheduling challenges in optimizing job-level performance objectives, where a significant challenge is the scheduling of highly parallel data flows with a common performance goal (e.g., the shuffle operations in MapReduce applications). Chowdhury and Stoica introduced the coflow abstraction to capture these parallel communication patterns, and Chowdhury et al. proposed effective heuristics to schedule coflows efficiently. In our previous paper, we considered the strongly NP-hard problem of minimizing the total weighted completion time of coflows with release dates, and developed the first polynomial-time scheduling algorithms with O(1)-approximation ratios. In this paper, we carry out a comprehensive experimental analysis on a Facebook trace and extensive simulated instances to evaluate the practical performance of several algorithms for coflow scheduling, including the approximation algorithms developed in our previous paper. Our experiments suggest that simple algorithms provide effective approximations of the optimal, and that the performance of our approximation algorithms is relatively robust, near optimal, and always among the best compared with the other algorithms, in both the offline and online settings.Comment: 29 pages, 8 figures, 11 table

A parametric framework for reversible pi-calculi

This paper presents a study of causality in a reversible, concurrent setting. There exist various notions of causality inπ-calculus, which differ in the treatment of parallel extrusions of the same name. Hence, by using a parametric way of bookkeeping the order and the dependencies among extruders it is possible to map different causal semantics into the same framework. Starting from this simple observation, we present a uniform framework forreversibleπ-calculi that is parametric with respect to a data structure that stores information about the extrusion of a name. Different data structures yield different approaches to the parallel extrusion problem. We map three well-known causal semantics into our framework. We prove causal-consistency for the three instances of our framework. Furthermore, we prove a causal correspondence between the appropriate instances of the framework and the Boreale-Sangiorgi semantics and an operational correspondence with the reversibleπ-calculus causal semantics

On Packet Scheduling with Adversarial Jamming and Speedup

In Packet Scheduling with Adversarial Jamming packets of arbitrary sizes arrive over time to be transmitted over a channel in which instantaneous jamming errors occur at times chosen by the adversary and not known to the algorithm. The transmission taking place at the time of jamming is corrupt, and the algorithm learns this fact immediately. An online algorithm maximizes the total size of packets it successfully transmits and the goal is to develop an algorithm with the lowest possible asymptotic competitive ratio, where the additive constant may depend on packet sizes. Our main contribution is a universal algorithm that works for any speedup and packet sizes and, unlike previous algorithms for the problem, it does not need to know these properties in advance. We show that this algorithm guarantees 1-competitiveness with speedup 4, making it the first known algorithm to maintain 1-competitiveness with a moderate speedup in the general setting of arbitrary packet sizes. We also prove a lower bound of $\phi+1\approx 2.618$ on the speedup of any 1-competitive deterministic algorithm, showing that our algorithm is close to the optimum. Additionally, we formulate a general framework for analyzing our algorithm locally and use it to show upper bounds on its competitive ratio for speedups in $[1,4)$ and for several special cases, recovering some previously known results, each of which had a dedicated proof. In particular, our algorithm is 3-competitive without speedup, matching both the (worst-case) performance of the algorithm by Jurdzinski et al. and the lower bound by Anta et al.Comment: Appeared in Proc. of the 15th Workshop on Approximation and Online Algorithms (WAOA 2017

Autonomous Detection of the Loss of a Wing for Underwater Gliders

Over the past five years, two of the Slocum underwater gliders operated by the UK National Oceanography Centre have lost a wing mid-mission without the pilot being aware of the problem until the point of vehicle retrieval. In this study, the steady-state data collected by gliders during the two deployments has been analysed to develop a fault detection system. From the data analysis, it is clear that the loss of the wing was a sudden event for both gliders. The main changes to the system dynamics associated with the event are an increase in the positive buoyancy of the glider and the occurrence of a roll angle on the side of the lost wing, with significant difference between dives and climbs. Hence, a simple effective system for the detection of the wing loss has been designed using the roll angle. Since sensors are known to fail and the roll sensor is non-critical to the operation of the glider, a back-up diagnostics system has been developed based on the dynamic model of the vehicle, capturing the change in buoyancy. Both systems are able to correctly detect the loss of the wing and notify pilots, who can re-plan missions to safely recover the vehicle

A degradatory fate for CCR4 suggests a primary role in Th2 inflammation.

CCR4 is the sole receptor for the chemokines CCL22 and CCL17. Clinical studies of asthmatic airways have shown levels of both ligands and CCR4+ Th2 cells to be elevated, suggestive of a role in disease. Consequently, CCR4 has aroused much interest as a potential therapeutic target and an understanding of how its cell surface expression is regulated is highly desirable. To this end, receptor expression, receptor endocytosis, and chemotaxis were assessed using transfectants expressing CCR4, CCR4+ human T cell lines, and human Th2 cells polarized in vitro. CCL17 and CCL22 drove rapid endocytosis of CCR4 in a dose-dependent manner. Replenishment at the cell surface was slow and sensitive to cycloheximide, suggestive of de novo synthesis of CCR4. Constitutive CCR4 endocytosis was also observed, with the internalized CCR4 found to be significantly degraded over a 6-h incubation. Truncation of the CCR4 C-terminus by 40 amino acids had no effect on cell surface expression, but resulted in significant impairment of ligand-induced endocytosis. Consequently, migration to both CCL17 and CCL22 was significantly enhanced. In contrast, truncation of CCR4 did not impair constitutive endocytosis or degradation, suggesting the use of alternative receptor motifs in these processes. We conclude that CCR4 cell surface levels are tightly regulated, with a degradative fate for endocytosed receptor. We postulate that this strict control is desirable, given that Th2 cells recruited by CCR4 can induce the further expression of CCR4 ligands in a positive feedback loop, thereby enhancing allergic inflammation